ExplorEnz: EC 1.14.19.53

Your query returned 1 entry. Printable version

1.14.19.53

Accepted name:

all-trans-retinol 3,4-desaturase

Reaction:

all-trans-retinol + 2 reduced adrenodoxin + 2 H⁺ + O₂ = all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H₂O

For diagram of retinal and derivatives biosynthesis, click here

Other name(s):

CYP27C1 (gene name)

Systematic name:

all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase

Comments:

A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Enright, J.M., Toomey, M.B., Sato, S.Y., Temple, S.E., Allen, J.R., Fujiwara, R., Kramlinger, V.M., Nagy, L.D., Johnson, K.M., Xiao, Y., How, M.J., Johnson, S.L., Roberts, N.W., Kefalov, V.J., Guengerich, F.P. and Corbo, J.C. Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A₁ into A2. Curr. Biol. 25 (2015) 3048–3057. [DOI] [PMID: 26549260]
2.	Kramlinger, V.M., Nagy, L.D., Fujiwara, R., Johnson, K.M., Phan, T.T., Xiao, Y., Enright, J.M., Toomey, M.B., Corbo, J.C. and Guengerich, F.P. Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids. FEBS Lett. 590 (2016) 1304–1312. [DOI] [PMID: 27059013]

[EC 1.14.19.53 created 2018]