The Enzyme Database

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EC 1.14.18.1     
Accepted name: monophenol monooxygenase
Reaction: L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O
Other name(s): tyrosinase; phenolase; monophenol oxidase; cresolase; catechol oxidase; polyphenolase; pyrocatechol oxidase; dopa oxidase; chlorogenic oxidase; catecholase; polyphenol oxidase; monophenolase; o-diphenol oxidase; chlorogenic acid oxidase; diphenol oxidase; o-diphenolase; tyrosine-dopa oxidase; o-diphenol:oxygen oxidoreductase; polyaromatic oxidase; monophenol monooxidase; o-diphenol oxidoreductase; monophenol dihydroxyphenylalanine:oxygen oxidoreductase; N-acetyl-6-hydroxytryptophan oxidase; monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase; o-diphenol:O2 oxidoreductase; phenol oxidase
Systematic name: monophenol,L-dopa:oxygen oxidoreductase
Comments: A group of copper proteins that also catalyse the reaction of EC 1.10.3.1 catechol oxidase, if only 1,2-benzenediols are available as substrate.
Links to other databases: BRENDA, EXPASY, IUBMB, KEGG, CAS registry number: 9002-10-2
References:
1.  Dawson, C.R. and Tarpley, W.B. The copper oxidases. In: Sumner, J.B. and Myrbäck, K. (Eds), The Enzymes, 1st edn, vol. 2, Academic Press, New York, 1951, pp. 454–498.
2.  Lerch, K. Amino acid sequence of tyrosinase from Neurospora crassa. Proc. Natl Acad. Sci. USA 75 (1978) 3605–3609. [PMID: 151279]
3.  Malmström, B.G., Andréasson, L.-E. and Reinhammar, B. Copper-containing oxidases and superoxide dismutase. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn, vol. 12, Academic Press, New York, 1975, pp. 507–579.
4.  McIntyre, R.J. and Vaughan, P.F.T. Kinetic studies on the hydroxylation of p-coumaric acid to caffeic acid by spinach-beet phenolase. Biochem. J. 149 (1975) 447–461. [PMID: 170916]
5.  Patil, S.S. and Zucker, M. Potato phenolases. Purification and properties. J. Biol. Chem. 240 (1965) 3938–3943. [PMID: 5842066]
6.  Pomerantz, S.H. Separation, purification, and properties of two tyrosinases from hamster melanoma. J. Biol. Chem. 238 (1963) 2351–2357. [PMID: 13972077]
7.  Robb, D.A. `Tyrosinase. In: Lontie, R. (Ed.), Copper Proteins and Copper Enzymes, vol. 2, CRC Press, Boca Raton, FL, 1984, pp. 207–240.
[EC 1.14.18.1 created 1972, modified 1976, modified 1980 (EC 1.14.17.2 created 1972, incorporated 1984)]
 
 


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