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Your query returned 1 entry. 
Printable version
| EC | 1.14.15.34 | ||||
| Accepted name: | 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase | ||||
| Reaction: | 20-oxo-5-O-β-mycaminosyltylactone + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 5-O-β-mycaminosyltylonolide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | ||||
| For diagram of tylosin biosynthesis, click here | |||||
| Glossary: | tylactone = (4R,5S,6S,7S,9R,11E,13E,15S,16R)-7,16-diethyl-4,6-dihydroxy-5,9,13,15-tetramethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione α-D-mycaminose = 3-dimethylamino-3,6-dideoxy-α-D-glucopyranose tylonolide = 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-16-ethyl-4,6-dihydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde |
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| Other name(s): | tylH1 (gene name) | ||||
| Systematic name: | 20-oxo-5-O-β-mycaminosyltylactone,reduced ferredoxin:oxygen oxidoreductase (23-hydroxylating) | ||||
| Comments: | A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
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