ExplorEnz: EC 1.14.15.11

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1.14.15.11

Accepted name:

pentalenic acid synthase

Reaction:

1-deoxypentalenate + reduced ferredoxin + O₂ = pentalenate + oxidized ferredoxin + H₂O

For diagram of pentalenolactone biosynthesis, click here

Glossary:

1-deoxypentalenate = (1R,3aR,5aS,8aR)-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate
pentalenate = (1R,3aR,5aS,6R,8aS)-6-hydroxy-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylate

Other name(s):

CYP105D7; sav7469 (gene name); 1-deoxypentalenate,reduced ferredoxin:O₂ oxidoreductase

Systematic name:

1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase

Comments:

A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Takamatsu, S., Xu, L.H., Fushinobu, S., Shoun, H., Komatsu, M., Cane, D.E. and Ikeda, H. Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis. J. Antibiot. (Tokyo) 64 (2011) 65–71. [DOI] [PMID: 21081950]

[EC 1.14.15.11 created 2012]