EC |
1.14.14.54 |
Accepted name: |
phenylacetate 2-hydroxylase |
Reaction: |
phenylacetate + [reduced NADPH—hemoprotein reductase] + O2 = (2-hydroxyphenyl)acetate + [oxidized NADPH—hemoprotein reductase] + H2O |
Other name(s): |
CYP504; phaA (gene name) |
Systematic name: |
phenylacetate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating) |
Comments: |
This cytochrome P-450 (heme-thiolate) enzyme, found in Aspergillus nidulans, is involved in the degradation of phenylacetate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Mingot, J.M., Penalva, M.A. and Fernandez-Canon, J.M. Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction. J. Biol. Chem. 274 (1999) 14545–14550. [DOI] [PMID: 10329644] |
2. |
Rodriguez-Saiz, M., Barredo, J.L., Moreno, M.A., Fernandez-Canon, J.M., Penalva, M.A. and Diez, B. Reduced function of a phenylacetate-oxidizing cytochrome P450 caused strong genetic improvement in early phylogeny of penicillin-producing strains. J. Bacteriol. 183 (2001) 5465–5471. [DOI] [PMID: 11544206] |
|
[EC 1.14.14.54 created 2017] |
|
|
|
|