ExplorEnz: EC 1.14.14.11

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1.14.14.11

Accepted name:

styrene monooxygenase

Reaction:

styrene + FADH₂ + O₂ = (S)-2-phenyloxirane + FAD + H₂O

Other name(s):

StyA; SMO; NSMOA

Systematic name:

styrene,FADH₂:oxygen oxidoreductase

Comments:

The enzyme catalyses the first step in the aerobic styrene degradation pathway. It forms a two-component system with a reductase (StyB) that utilizes NADH to reduce flavin-adenine dinucleotide, which is then transferred to the oxygenase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Otto, K., Hofstetter, K., Rothlisberger, M., Witholt, B. and Schmid, A. Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenase. J. Bacteriol. 186 (2004) 5292–5302. [DOI] [PMID: 15292130]
2.	Tischler, D., Kermer, R., Groning, J.A., Kaschabek, S.R., van Berkel, W.J. and Schlomann, M. StyA1 and StyA2B from Rhodococcus opacus 1CP: a multifunctional styrene monooxygenase system. J. Bacteriol. 192 (2010) 5220–5227. [DOI] [PMID: 20675468]

[EC 1.14.14.11 created 2011]