The Enzyme Database

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Accepted name: deoxysarpagine hydroxylase
Reaction: 10-deoxysarpagine + NADPH + H+ + O2 = sarpagine + NADP+ + H2O
For diagram of geissoschizine and sarpagine biosynthesis, click here
Other name(s): DOSH
Systematic name: 10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating)
Comments: A heme-thiolate protein (P-450).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Yu, B., Ruppert, M. and Stöckigt, J. Deoxysarpagine hydroxylase — a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia. Bioorg. Med. Chem. 10 (2002) 2479–2483. [DOI] [PMID: 12057637]
[EC created 2005]

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