| EC |
1.14.13.9 |
| Accepted name: |
kynurenine 3-monooxygenase |
| Reaction: |
L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O |
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For diagram of tryptophan catabolism, click here |
| Other name(s): |
kynurenine 3-hydroxylase; kynurenine hydroxylase; L-kynurenine-3-hydroxylase |
| Systematic name: |
L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating) |
| Comments: |
A flavoprotein (FAD). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9029-61-2 |
| References: |
| 1. |
de Castro, F.T., Price, J.M. and Brown, R.R. Reduced triphosphopyridinenucleotide requirement for the enzymatic formation of 3-hydroxykynurenine from L-kynurenine. J. Am. Chem. Soc. 78 (1956) 2904–2905. |
| 2. |
Okamoto, H. and Hayaishi, O. Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria. Biochem. Biophys. Res. Commun. 29 (1967) 394–399. [DOI] [PMID: 6076241] |
| 3. |
Saito, Y., Hayaishi, O. and Rothberg, S. Studies on oxygenases: enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine. J. Biol. Chem. 229 (1957) 921–934. [PMID: 13502353] |
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| [EC 1.14.13.9 created 1961 as EC 1.99.1.5, transferred 1965 to EC 1.14.1.2, transferred 1972 to EC 1.14.13.9] |
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