The Enzyme Database

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Accepted name: vinorine hydroxylase
Reaction: vinorine + NADPH + H+ + O2 = vomilenine + NADP+ + H2O
For diagram of ajmaline, vinorine, vomilenine and raucaffricine biosynthesis, click here
Systematic name: vinorine,NADPH:oxygen oxidoreductase (21α-hydroxylating)
Comments: A heme-thiolate protein (P-450). Forms a stage in the biosynthesis of the indole alkaloid ajmaline.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 162875-03-8
1.  Falkenhagen, H. and Stöckligt, J. Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway, catalysed by a novel cytochrome P-450-dependent enzyme from plant cell cultures of Rauwolfia serpentina. Z. Naturforsch. C: Biosci. 50 (1995) 45–53.
[EC created 2002]

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