The Enzyme Database

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Accepted name: dihydrosanguinarine 10-monooxygenase
Reaction: dihydrosanguinarine + NADPH + H+ + O2 = 10-hydroxydihydrosanguinarine + NADP+ + H2O
For diagram of chelirubine, macarpine and sanguinarine biosynthesis, click here
Other name(s): dihydrosanguinarine 10-hydroxylase
Systematic name: dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)
Comments: A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 144388-41-0
1.  De-Eknamkul, W., Tanahashi, T. and Zenk, M.H. Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia. Phytochemistry 31 (1992) 2713–2717.
[EC created 1999]

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