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Accepted name: protopine 6-monooxygenase
Reaction: protopine + NADPH + H
+ O + = 6-hydroxyprotopine + NADP 2 + H + O 2
For diagram of stylopine biosynthesis,
Other name(s): protopine 6-hydroxylase
Systematic name: protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)
Comments: A heme-thiolate protein (
P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 128561-60-4
Tanahashi, T. and Zenk, M.H. Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis.
Phytochemistry 29 (1990) 1113–1122.
[EC 184.108.40.206 created 1999]
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