The Enzyme Database

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Accepted name: 4′-methoxyisoflavone 2′-hydroxylase
Reaction: formononetin + NADPH + H+ + O2 = 2′-hydroxyformononetin + NADP+ + H2O
For diagram of the biosynthesis of formononetin and derivatives, click here
Other name(s): isoflavone 2′-monooxygenase (ambiguous); isoflavone 2′-hydroxylase (ambiguous)
Systematic name: formononetin,NADPH:oxygen oxidoreductase (2′-hydroxylating)
Comments: A heme-thiolate protein (P-450). Acts on isoflavones with a 4′-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC, isoflavone 2′-hydroxylase, is less specific and acts on other isoflavones as well as 4′-methoxyisoflavones.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 110183-49-8
1.  Hinderer, W., Flentje, U. and Barz, W. Microsomal isoflavone 2′-hydroxylases and 3′-hydroxylases from chickpea (Cicer arietinum L) cell-suspensions induced for pterocarpan phytoalexin formation. FEBS Lett. 214 (1987) 101–106.
[EC created 1992, modified 2005]

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