The Enzyme Database

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Accepted name: (S)-limonene 6-monooxygenase
Reaction: (S)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O
For diagram of perillyl alcohol, isopiperitol and carveol biosynthesis, click here
Glossary: limonene = a monoterpenoid
(S)-limonene = (-)-limonene
Other name(s): (-)-limonene 6-hydroxylase; (-)-limonene 6-monooxygenase; (-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Systematic name: (S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Comments: High specificity, but NADH can act instead of NADPH, but more slowly. A heme-thiolate protein (P-450).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 138066-93-0
1.  Karp, F., Mihaliak, C.A., Harris, J.L. and Croteau, R. Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. Arch. Biochem. Biophys. 276 (1990) 219–226. [PMID: 2297225]
[EC created 1992, modified 2003]

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