The Enzyme Database

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Accepted name: methyltetrahydroprotoberberine 14-monooxygenase
Reaction: (S)-N-methylcanadine + NADPH + H+ + O2 = allocryptopine + NADP+ + H2O
For diagram of stylopine biosynthesis, click here and for diagram of canadine biosynthesis, click here
Other name(s): methyltetrahydroprotoberberine 14-hydroxylase; (S)-cis-N-methyltetrahydroberberine 14-monooxygenase; (S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase
Systematic name: (S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)
Comments: A heme-thiolate protein (P-450).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 113478-42-5
1.  Rueffer, M. and Zenk, M.H. Enzymatic formation of protopines by a microsomal cytochrome-P-450 system of Corydalis vaginans. Tetrahedron Lett. 28 (1987) 5307–5310.
[EC created 1990]

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