| EC |
1.14.13.32 |
| Accepted name: |
albendazole monooxygenase |
| Reaction: |
albendazole + NADPH + H+ + O2 = albendazole S-oxide + NADP+ + H2O |
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For diagram of albendazole metabolism, click here |
| Glossary: |
albendazole = methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate |
| Other name(s): |
albendazole oxidase (misleading); albendazole sulfoxidase (ambiguous); FMO3 (gene name); albendazole monooxygenase (flavin-containing) |
| Systematic name: |
albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming) |
| Comments: |
A microsomal flavin-containing monooxygenase. A similar conversion is also carried out by some microsomal cytochrome P-450 enzymes [EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming)]. It is estimated that cytochrome P-450s are responsible for 70% of the activity. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 101299-59-6 |
| References: |
| 1. |
Fargetton, X., Galtier, P. and Delatour, P. Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes. Vet. Res. Commun. 10 (1986) 317–324. [PMID: 3739217] |
| 2. |
Moroni, P., Buronfosse, T., Longin-Sauvageon, C., Delatour, P. and Benoit, E. Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes. Drug Metab. Dispos. 23 (1995) 160–165. [PMID: 7736906] |
| 3. |
Rawden, H.C., Kokwaro, G.O., Ward, S.A. and Edwards, G. Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes. Br. J. Clin. Pharmacol. 49 (2000) 313–322. [PMID: 10759686] |
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| [EC 1.14.13.32 created 1989, modified 2018] |
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