ExplorEnz: EC 1.14.13.224

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1.14.13.224

Accepted name:

violacein synthase

Reaction:

(1) protoviolaceinate + NAD(P)H + O₂ = violaceinate + NAD(P)⁺ + H₂O
(2) protodeoxyviolaceinate + NAD(P)H + O₂ = deoxyviolaceinate + NAD(P)⁺ + H₂O

For diagram of violacein biosynthesis, click here

Glossary:

violacein = (3E)-3-[5-(5-hydroxy-1H-indol-3-yl)-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one

Other name(s):

proviolaceinate monooxygenase; vioC (gene name)

Systematic name:

protoviolaceinate,NAD(P)H:O₂ oxidoreductase

Comments:

The enzyme, characterized from the bacterium Chromobacterium violaceum, participates in the biosynthesis of the violet pigment violacein. The products, violaceinate and deoxyviolaceinate, undergo non-enzymic autooxidation into violacein and deoxyviolacein, respectively.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Balibar, C.J. and Walsh, C.T. In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. Biochemistry 45 (2006) 15444–15457. [DOI] [PMID: 17176066]
2.	Shinoda, K., Hasegawa, T., Sato, H., Shinozaki, M., Kuramoto, H., Takamiya, Y., Sato, T., Nikaidou, N., Watanabe, T. and Hoshino, T. Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function. Chem. Commun. (Camb.) (2007) 4140–4142. [DOI] [PMID: 17925955]

[EC 1.14.13.224 created 2016]