The Enzyme Database

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EC 1.14.13.203     
Accepted name: farnesoate epoxidase
Reaction: (2E,6E)-farnesoate + NADPH + H+ + O2 = juvenile-hormone-III carboxylate + NADP+ + H2O
For diagram of juvenile hormone biosynthesis, click here
Glossary: juvenile-hormone-III carboxylate = (2E,6E,10R)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate
Other name(s): CYP15C1
Systematic name: (2E,6E)-farnesoate,NADPH:oxygen oxidoreductase
Comments: A heme-thiolate protein (cytochrome P-450). The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.13.202, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Daimon, T., Kozaki, T., Niwa, R., Kobayashi, I., Furuta, K., Namiki, T., Uchino, K., Banno, Y., Katsuma, S., Tamura, T., Mita, K., Sezutsu, H., Nakayama, M., Itoyama, K., Shimada, T. and Shinoda, T. Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori. PLoS Genet 8:e1002486 (2012). [PMID: 22412378]
2.  Daimon, T. and Shinoda, T. Function, diversity, and application of insect juvenile hormone epoxidases (CYP15). Biotechnol. Appl. Biochem. 60 (2013) 82–91. [PMID: 23586995]
[EC 1.14.13.203 created 2015]
 
 


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