The Enzyme Database

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Accepted name: methyl farnesoate epoxidase
Reaction: methyl (2E,6E)-farnesoate + NADPH + H+ + O2 = juvenile hormone III + NADP+ + H2O
For diagram of juvenile hormone biosynthesis, click here
Glossary: juvenile hormone III = methyl (2E,6E,10R)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate
Other name(s): CYP15A1
Systematic name: methyl (2E,6E)-farnesoate,NADPH:oxygen oxidoreductase
Comments: A heme-thiolate protein (cytochrome P-450). The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC, farnesoate epoxidase) [1,2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Helvig, C., Koener, J.F., Unnithan, G.C. and Feyereisen, R. CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata. Proc. Natl. Acad. Sci. USA 101 (2004) 4024–4029. [DOI] [PMID: 15024118]
2.  Daimon, T. and Shinoda, T. Function, diversity, and application of insect juvenile hormone epoxidases (CYP15). Biotechnol. Appl. Biochem. 60 (2013) 82–91. [DOI] [PMID: 23586995]
[EC created 2015]

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