The Enzyme Database

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EC 1.14.13.189     
Accepted name: 5-methyl-1-naphthoate 3-hydroxylase
Reaction: 5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O
For diagram of the azinomycin biosynthesis (part of pathway), click here
Other name(s): AziB1
Systematic name: 5-methyl-1-naphthoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
Comments: The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Ding, W., Deng, W., Tang, M., Zhang, Q., Tang, G., Bi, Y. and Liu, W. Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B. Mol. Biosyst. 6 (2010) 1071–1081. [PMID: 20485749]
[EC 1.14.13.189 created 2014]
 
 


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