The Enzyme Database

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Accepted name: protopanaxadiol 6-hydroxylase
Reaction: protopanaxadiol + NADPH + H+ + O2 = protopanaxatriol + NADP+ + H2O
For diagram of dammarenediol II and tirucalla-7,24-dien-3β-ol biosynthesis, click here
Glossary: protopanaxadiol = dammar-24-ene-3β,12β,20-triol
protopanaxatriol = dammar-24-ene-3β,6α,12β,20-tetrol
Other name(s): protopanaxatriol synthase; P6H; CYP716A53v2; protopanaxadiol,NADPH:O2 oxidoreductase (6α-hydroxylating)
Systematic name: protopanaxadiol,NADPH:oxygen oxidoreductase (6α-hydroxylating)
Comments: A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from the rhizomes of ginseng (Panax ginseng).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Yue, C.J., Zhou, X. and Zhong, J.J. Protopanaxadiol 6-hydroxylase and its role in regulating the ginsenoside heterogeneity in Panax notoginseng cells. Biotechnol. Bioeng. 100 (2008) 933–940. [DOI] [PMID: 18351680]
2.  Han, J.Y., Hwang, H.S., Choi, S.W., Kim, H.J. and Choi, Y.E. Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol 53 (2012) 1535–1545. [DOI] [PMID: 22875608]
[EC created 2013]

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