The Enzyme Database

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Accepted name: dammarenediol 12-hydroxylase
Reaction: dammarenediol-II + NADPH + H+ + O2 = protopanaxadiol + NADP+ + H2O
For diagram of dammarenediol II and tirucalla-7,24-dien-3β-ol biosynthesis, click here
Glossary: dammarenediol-II = dammar-24-ene-3β,20-diol
protopanaxadiol = dammar-24-ene-3β,12β,20-triol
Other name(s): protopanaxadiol synthase; CYP716A47; dammarenediol-II,NADPH:O2 oxidoreductase (12β-hydroxylating)
Systematic name: dammarenediol-II,NADPH:oxygen oxidoreductase (12β-hydroxylating)
Comments: A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from ginseng (Panax ginseng).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Han, J.Y., Kim, H.J., Kwon, Y.S. and Choi, Y.E. The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol 52 (2011) 2062–2073. [DOI] [PMID: 22039120]
[EC created 2013]

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