The Enzyme Database

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EC 1.14.13.147     
Accepted name: taxoid 7β-hydroxylase
Reaction: taxusin + O2 + NADPH + H+ = 7β-hydroxytaxusin + NADP+ + H2O
Glossary: taxusin = taxa-4(20),11-diene-5α,9α,10β,13α-tetrayl tetraacetate
Systematic name: taxusin,NADPH:oxygen 7-oxidoreductase
Comments: Requires cytochrome P-450. From the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Chau, M., Jennewein, S., Walker, K. and Croteau, R. Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 β-hydroxylase. Chem. Biol. 11 (2004) 663–672. [PMID: 15157877]
[EC 1.14.13.147 created 2012]
 
 


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