The Enzyme Database

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EC 1.14.13.133     
Accepted name: pentalenene oxygenase
Reaction: pentalenene + 2 NADPH + 2 H+ + 2 O2 = pentalen-13-al + 2 NADP+ + 3 H2O (overall reaction)
(1a) pentalenene + NADPH + H+ + O2 = pentalen-13-ol + NADP+ + H2O
(1b) pentalen-13-ol + NADPH + H+ + O2 = pentalen-13-al + NADP+ + 2 H2O
For diagram of humulene-based sequiterpenoid biosynthesis, click here
Other name(s): PtlI
Systematic name: pentalenene,NADPH:oxygen 13-oxidoreductase
Comments: A heme-thiolate protein (P-450). The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Quaderer, R., Omura, S., Ikeda, H. and Cane, D.E. Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis. J. Am. Chem. Soc. 128 (2006) 13036–13037. [PMID: 17017767]
[EC 1.14.13.133 created 2011]
 
 


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