The Enzyme Database

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Accepted name: dimethyl-sulfide monooxygenase
Reaction: dimethyl sulfide + O2 + NADH + H+ = methanethiol + formaldehyde + NAD+ + H2O
For diagram of dimethyl sulfide catabolism, click here
Other name(s): dimethylsulfide monooxygenase
Systematic name: dimethyl sulfide,NADH:oxygen oxidoreductase
Comments: The enzyme has lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides. Its activity is stimulated by combined addition of FMN, and, after depletion of cations, of Mg2+ and Fe2+. The enzyme from Hyphomicrobium is a two component system that includes an FMN-dependent reductase subunit and a monooxygenase subunit.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  De Bont, J.A.M., Van Dijken, J.P. and Harder, W. Dimethyl sulphoxide and dimethyl sulphide as a carbon, sulphur and energy source for growth of Hyphomicrobium S. J. Gen. Microbiol. 127 (1981) 315–323.
2.  Boden, R., Borodina, E., Wood, A.P., Kelly, D.P., Murrell, J.C. and Schafer, H. Purification and characterization of dimethylsulfide monooxygenase from Hyphomicrobium sulfonivorans. J. Bacteriol. 193 (2011) 1250–1258. [DOI] [PMID: 21216999]
[EC created 2011]

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