The Enzyme Database

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Accepted name: nitric oxide dioxygenase
Reaction: 2 nitric oxide + 2 O2 + NAD(P)H = 2 nitrate + NAD(P)+ + H+
Glossary: nitric oxide = NO = nitrogen(II) oxide
Systematic name: nitric oxide,NAD(P)H:oxygen oxidoreductase
Comments: A flavohemoglobin (FAD). It has been proposed that FAD functions as the electron carrier from NADPH to the ferric heme prosthetic group.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 214466-78-1
1.  Gardner, P.R., Costantino, G. and Salzman, A.L. Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase. J. Biol. Chem. 273 (1998) 26528–26533. [PMID: 9756889]
2.  Gardner, P.R., Gardner, A.M., Martin, L.A. and Salzman, A.L. Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. Proc. Natl. Acad. Sci. USA 95 (1998) 10378–10383. [PMID: 9724711]
[EC created 2000]

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