ExplorEnz: EC 1.14.11.63

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1.14.11.63

Accepted name:

peptidyl-lysine (3S)-dioxygenase

Reaction:

a [protein]-L-lysine + 2-oxoglutarate + O₂ = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO₂

Other name(s):

JMJD7 (gene name); Jumonji domain-containing protein 7; JmjC domain-containing protein 7

Systematic name:

[protein]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating)

Comments:

Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Markolovic, S., Zhuang, Q., Wilkins, S.E., Eaton, C.D., Abboud, M.I., Katz, M.J., McNeil, H.E., Lesniak, R.K., Hall, C., Struwe, W.B., Konietzny, R., Davis, S., Yang, M., Ge, W., Benesch, J.LP., Kessler, B.M., Ratcliffe, P.J., Cockman, M.E., Fischer, R., Wappner, P., Chowdhury, R., Coleman, M.L. and Schofield, C.J. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nat. Chem. Biol. 14 (2018) 688–695. [PMID: 29915238]

[EC 1.14.11.63 created 2019]