| EC |
1.14.11.6 |
| Accepted name: |
thymine dioxygenase |
| Reaction: |
thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2 |
| Other name(s): |
thymine 7-hydroxylase; 5-hydroxy-methyluracil dioxygenase; 5-hydroxymethyluracil oxygenase |
| Systematic name: |
thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating) |
| Comments: |
Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37256-67-0 |
| References: |
| 1. |
Bankel, L., Holme, E., Lindstedt, G. and Lindstedt, S. Oxygenases involved in thymine and thymidine metabolism in Neurospora crassa. FEBS Lett. 21 (1972) 135–138. [DOI] [PMID: 11946494] |
| 2. |
Liu, C.-K., Hsu, C.-A. and Abbott, M.T. Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase. Arch. Biochem. Biophys. 159 (1973) 180–187. [DOI] [PMID: 4274083] |
| 3. |
Warn-Cramer, B.J., Macrander, L.A. and Abbott, M.T. Markedly different ascorbate dependencies of the sequential α-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis. J. Biol. Chem. 258 (1983) 10551–10557. [PMID: 6684117] |
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| [EC 1.14.11.6 created 1972, modified 1976 (EC 1.14.11.5 created 1972, incorporated 1976)] |
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