Accepted name: enduracididine β-hydroxylase
Reaction: L-enduracididine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-enduracididine + succinate + CO2
Glossary: L-enduracididine = 3-[(4R)-2-iminoimidazolidin-4-yl]-L-alanine = 2-amino-3-[(2S)-iminoimidazolin-4-yl]propanoic acid
(3S)-3-hydroxy-L-enduracididine = (2S,3R)-2-amino-3-hydroxy-3-[(S)-2-iminoimidazolidin-4-yl]propanoic acid = (3R)-3-[(4S)-2-iminoimidazolidin-4-yl]-L-serine
Other name(s): MppO; L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating)
Systematic name: L-enduracididine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Comments: Fe2+-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid β-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439.
1.  Haltli, B., Tan, Y., Magarvey, N.A., Wagenaar, M., Yin, X., Greenstein, M., Hucul, J.A. and Zabriskie, T.M. Investigating β-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins. Chem. Biol. 12 (2005) 1163–1168. [PMID: 16298295]
2.  Magarvey, N.A., Haltli, B., He, M., Greenstein, M. and Hucul, J.A. Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens. Antimicrob. Agents Chemother. 50 (2006) 2167–2177. [PMID: 16723579]
[EC created 2013]

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