EC |
1.14.11.31 |
Accepted name: |
thebaine 6-O-demethylase |
Reaction: |
thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + CO2 |
Other name(s): |
T6ODM |
Systematic name: |
thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating) |
Comments: |
Requires Fe2+. Catalyses a step in morphine biosynthesis. The product neopinione spontaneously rearranges to the more stable codeinone. The enzyme also catalyses the 6-O-demethylation of oripavine to morphinone, with lower efficiency. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Hagel, J.M. and Facchini, P.J. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nat. Chem. Biol. 6 (2010) 273–275. [DOI] [PMID: 20228795] |
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[EC 1.14.11.31 created 2010] |
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