| EC |
1.14.11.16 |
| Accepted name: |
peptide-aspartate β-dioxygenase |
| Reaction: |
peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 |
| Other name(s): |
aspartate β-hydroxylase; aspartylpeptide β-dioxygenase |
| Systematic name: |
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) |
| Comments: |
Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 122544-66-5 |
| References: |
| 1. |
Gronke, R.S., Welsch, D.J., VanDusen, W.J., Garsky, V.M., Sardana, M.K., Stern, A.M. and Friedman, P.A. Partial purification and characterization of bovine liver aspartyl β-hydroxylase. J. Biol. Chem. 265 (1990) 8558–8565. [PMID: 2187868] |
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| [EC 1.14.11.16 created 1992] |
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