| EC |
1.13.11.9 |
| Accepted name: |
2,5-dihydroxypyridine 5,6-dioxygenase |
| Reaction: |
2,5-dihydroxypyridine + O2 = N-formylmaleamic acid |
| Other name(s): |
2,5-dihydroxypyridine oxygenase; pyridine-2,5-diol dioxygenase; NicX |
| Systematic name: |
2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase |
| Comments: |
Requires Fe2+. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9029-57-6 |
| References: |
| 1. |
Behrman, E.J. and Stanier, R.Y. The bacterial oxidation of nicotinic acid. J. Biol. Chem. 228 (1957) 923–945. [PMID: 13475371] |
| 2. |
Gauthier, J.J. and Rittenberg, S.C. The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9. J. Biol. Chem. 246 (1971) 3737–3742. [PMID: 5578917] |
| 3. |
Gauthier, J.J. and Rittenberg, S.C. The metabolism of nicotinic acid. II. 2,5-Dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation. J. Biol. Chem. 246 (1971) 3743–3748. [PMID: 5578918] |
| 4. |
Jimenez, J.I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J.L. and Diaz, E. Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440. Proc. Natl. Acad. Sci. USA 105 (2008) 11329–11334. [DOI] [PMID: 18678916] |
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| [EC 1.13.11.9 created 1965 as EC 1.13.1.9, transferred 1972 to EC 1.13.11.9, modified 2010] |
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