EC |
1.13.11.86 |
Accepted name: |
5-aminosalicylate 1,2-dioxygenase |
Reaction: |
5-aminosalicylate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate |
Glossary: |
5-aminosalicylate = 5-amino-2-hydroxybenzoate |
Other name(s): |
mabB (gene name) |
Systematic name: |
5-aminosalicylate:oxygen 1,2-oxidoreductase (ring-opening) |
Comments: |
Requires iron(II). The enzyme, characterized from different bacteria, is a nonheme iron dioxygenase in the bicupin family. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Stolz, A., Nortemann, B. and Knackmuss, H.J. Bacterial metabolism of 5-aminosalicylic acid. Initial ring cleavage. Biochem. J. 282 (1992) 675–680. [PMID: 1554350] |
2. |
Yu, H., Zhao, S. and Guo, L. Novel gene encoding 5-aminosalicylate 1,2-dioxygenase from Comamonas sp. strain QT12 and catalytic properties of the purified enzyme. J. Bacteriol. 200 (2018) . [PMID: 29038259] |
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[EC 1.13.11.86 created 2018] |
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