The Enzyme Database

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EC 1.13.11.67     
Accepted name: 8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase
Reaction: 8′-apo-β-carotenol + O2 = 14′-apo-β-carotenal + an uncharacterized product
For diagram of 8′-apo-β-carotenal metabolites, click here
Other name(s): 8′-apo-β-carotenol:O2 oxidoreductase (14′,13′-cleaving)
Systematic name: 8′-apo-β-carotenol:oxygen oxidoreductase (14′,13′-cleaving)
Comments: A thiol-dependent enzyme isolated from rat and rabbit. Unlike EC 1.13.11.63, β-carotene-15,15′-dioxygenase, it is not active towards β-carotene. The secondary product has not been characterized, but may be (3E,5E)-7-hydroxy-6-methylhepta-3,5-dien-2-one.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 198028-39-6
References:
1.  Dmitrovskii, A.A., Gessler, N.N., Gomboeva, S.B., Ershov, Yu.V. and Bykhovsky, V.Ya. Enzymatic oxidation of β-apo-8′-carotenol to β-apo-14′-carotenal by an enzyme different from β-carotene-15,15′-dioxygenase. Biochemistry (Mosc) 62 (1997) 787–792. [PMID: 9331970]
[EC 1.13.11.67 created 2000 as EC 1.13.12.12, transferred 2012 to EC 1.13.11.67]
 
 


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