The Enzyme Database

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Accepted name: hydroquinone 1,2-dioxygenase
Reaction: benzene-1,4-diol + O2 = (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate
For diagram of 4-nitrophenol metabolism, click here
Glossary: benzene-1,4-diol = hydroquinone
(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate = 4-hydroxymuconic semialdehyde
Other name(s): hydroquinone dioxygenase; benzene-1,4-diol:oxygen 1,2-oxidoreductase (decyclizing)
Systematic name: benzene-1,4-diol:oxygen 1,2-oxidoreductase (ring-opening)
Comments: The enzyme is an extradiol-type dioxygenase, and is a member of the nonheme-iron(II)-dependent dioxygenase family. It catalyses the ring cleavage of a wide range of hydroquinone substrates to produce the corresponding 4-hydroxymuconic semialdehydes.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Miyauchi, K., Adachi, Y., Nagata, Y. and Takagi, M. Cloning and sequencing of a novel meta-cleavage dioxygenase gene whose product is involved in degradation of γ-hexachlorocyclohexane in Sphingomonas paucimobilis. J. Bacteriol. 181 (1999) 6712–6719. [PMID: 10542173]
2.  Moonen, M.J., Synowsky, S.A., van den Berg, W.A., Westphal, A.H., Heck, A.J., van den Heuvel, R.H., Fraaije, M.W. and van Berkel, W.J. Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases. J. Bacteriol. 190 (2008) 5199–5209. [PMID: 18502867]
3.  Shen, W., Liu, W., Zhang, J., Tao, J., Deng, H., Cao, H. and Cui, Z. Cloning and characterization of a gene cluster involved in the catabolism of p-nitrophenol from Pseudomonas putida DLL-E4. Bioresour. Technol. 101 (2010) 7516–7522. [PMID: 20466541]
[EC created 2012]

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