ExplorEnz: EC 1.13.11.45

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1.13.11.45

Accepted name:

linoleate 11-lipoxygenase

Reaction:

linoleate + O₂ = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate

Glossary:

arachidonate = (all-Z)-icosa-5,8,11,14-tetraenoate
linoleate = (9Z,12Z)-octadeca-9,12-dienoate
α-linolenate = (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
γ-linolenate = (6Z,9Z,12Z)-octadeca-6,9,12-trienoate
oleate = (Z)-octadec-9-enoate

Other name(s):

linoleate dioxygenase; manganese lipoxygenase

Systematic name:

linoleate:oxygen 11S-oxidoreductase

Comments:

The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13-hydroperoxyoctadeca-9,11-dienoate. The enzyme from the fungus Gaeumannomyces graminis requires Mn²⁺. It also acts on α-linolenate, whereas γ-linolenate is a poor substrate. Oleate and arachidonate are not substrates.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Hamberg, M., Su, C. and Oliw, E.H. Manganese lipoxygenase: Discovery of bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction. J. Biol. Chem. 273 (1998) 13080–13088. [DOI] [PMID: 9582346]
2.	Oliw, E.H., Su, C., Skogstrom, T. and Benthin, G. Analysis of novel hydroperoxides and other metabolites of oleic, linoleic and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn. Lipids 33 (1998) 843–852. [DOI] [PMID: 9778131]
3.	Su, C. and Oliw, E.H. Manganese lipoxygenase: Purification and characterization. J. Biol. Chem. 273 (1998) 13072–13079. [DOI] [PMID: 9582345]

[EC 1.13.11.45 created 2000]