| EC |
1.13.11.17 |
| Accepted name: |
indole 2,3-dioxygenase |
| Reaction: |
indole + O2 = 2-formylaminobenzaldehyde |
| Other name(s): |
indole oxidase; indoleamine 2,3-dioxygenase (ambiguous); indole:O2 oxidoreductase; indole-oxygen 2,3-oxidoreductase (decyclizing); IDO (ambiguous); indole:oxygen 2,3-oxidoreductase (decyclizing) |
| Systematic name: |
indole:oxygen 2,3-oxidoreductase (ring-opening) |
| Comments: |
Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37256-57-8 |
| References: |
| 1. |
Nair, P.M. and Vaidyanathan, C.S. An indole oxidase isolated from the leaves of Tecoma stans. Biochim. Biophys. Acta 81 (1964) 496–506. [PMID: 14170321] |
| 2. |
Chauhan, Y.S., Rathore, V.S., Garg, G.K. and Bhargava, A. Detection of an indole oxidizing system in maize leaves. Biochem. Biophys. Res. Commun. 83 (1978) 1237–1245. [DOI] [PMID: 697856] |
| 3. |
Divakar, N.G., Subramanian, V., Sugumaran, M. and Vaidyanathan, C.S. Indole oxygenase from the leaves of Jasminum grandiflorum. Plant Sci. Lett. 15 (1979) 177–181. |
| 4. |
Kunapuli, S.P. and Vaidyanathan, C.S. Purification and characterization of a new indole oxygenase from the leaves of Tecoma stans L. Plant Physiol. 71 (1983) 19–23. [PMID: 16662784] |
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| [EC 1.13.11.17 created 1972, modified 1986] |
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