The Enzyme Database

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EC 1.12.99.6     
Accepted name: hydrogenase (acceptor)
Reaction: H2 + acceptor = reduced acceptor
Other name(s): H2 producing hydrogenase (ambiguous); hydrogen-lyase (ambiguous); hydrogenlyase (ambiguous); uptake hydrogenase (ambiguous); hydrogen:(acceptor) oxidoreductase
Systematic name: hydrogen:acceptor oxidoreductase
Comments: Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9027-05-8
References:
1.  Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R. The role of molybdenum and flavin in hydrogenase. J. Am. Chem. Soc. 76 (1954) 3355–3356.
2.  Adams, M.W.W., Mortenson, L.E. and Chen, J.-S. Hydrogenase. Biochim. Biophys. Acta 594 (1981) 105–176. [PMID: 6786341]
3.  Vignais, P.M., Billoud, B. and Meyer, J. Classification and phylogeny of hydrogenases. FEMS Microbiol. Rev. 25 (2001) 455–501. [PMID: 11524134]
[EC 1.12.99.6 created 2002, modified 2003]
 
 


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