An iron-sulfur protein. The enzyme from the hyperthermophilic archaeon Pyrococcus furiosus is part of two heterotetrameric complexes where the β and γ subunits function as sulfur reductase and the α and δ subunits function as hydrogenases (EC 188.8.131.52, hydrogen dehydrogenase [NADP+] and EC 184.108.40.206, hydrogen dehydrogenase [NAD(P)+], respectively). Sulfur can also be used as substrate, but since it is insoluble in aqueous solution and polysulfide is generated abiotically by the reaction of hydrogen sulfide and sulfur, polysulfide is believed to be the true substrate .
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[EC 220.127.116.11 created 1992 as EC 18.104.22.168, transferred 2013 to EC 22.214.171.124]