A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the α and δ subunits function as a hydrogenase while the β and γ subunits function as sulfur reductase (EC 18.104.22.168, sulfhydrogenase). Different from EC 22.214.171.124, hydrogen dehydrogenase (NADP+).
Ma, K., Weiss, R. and Adams, M.W. Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction. J. Bacteriol.182 (2000) 1864–1871. [DOI] [PMID: 10714990]