The Enzyme Database

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EC 1.12.1.5     
Accepted name: hydrogen dehydrogenase [NAD(P)+]
Reaction: H2 + NAD(P)+ = H+ + NAD(P)H
Other name(s): hydrogenase II (ambiguous)
Systematic name: hydrogen:NAD(P)+ oxidoreductase
Comments: A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the α and δ subunits function as a hydrogenase while the β and γ subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Ma, K., Weiss, R. and Adams, M.W. Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction. J. Bacteriol. 182 (2000) 1864–1871. [PMID: 10714990]
[EC 1.12.1.5 created 2013]
 
 


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