ExplorEnz: EC 1.10.3.17

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1.10.3.17

Accepted name:

superoxide oxidase

Reaction:

2 O₂ + ubiquinol = 2 superoxide + ubiquinone + 2 H⁺

Other name(s):

SOO; CybB; cytochrome b₅₆₁; superoxide:ubiquinone oxidoreductase

Systematic name:

ubiquinol:oxygen oxidoreductase (superoxide-forming)

Comments:

This membrane-bound, di-heme containing enzyme, identified in the bacterium Escherichia coli, is responsible for the detoxification of superoxide in the periplasm. In vivo the reaction proceeds in the opposite direction of that shown and produces oxygen. Superoxide production was only observed when the enzyme was incubated in vitro with an excess of ubiquinol.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Murakami, H., Kita, K. and Anraku, Y. Cloning of cybB, the gene for cytochrome b₅₆₁ of Escherichia coli K12. Mol. Gen. Genet. 198 (1984) 1–6. [PMID: 6097799]
2.	Murakami, H., Kita, K. and Anraku, Y. Purification and properties of a diheme cytochrome b₅₆₁ of the Escherichia coli respiratory chain. J. Biol. Chem. 261 (1986) 548–551. [PMID: 3510204]
3.	Lundgren, C.AK., Sjostrand, D., Biner, O., Bennett, M., Rudling, A., Johansson, A.L., Brzezinski, P., Carlsson, J., von Ballmoos, C. and Hogbom, M. Scavenging of superoxide by a membrane-bound superoxide oxidase. Nat. Chem. Biol. 14 (2018) 788–793. [PMID: 29915379]

[EC 1.10.3.17 created 2019]