ExplorEnz: EC 1.10.3.16

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1.10.3.16

Accepted name:

dihydrophenazinedicarboxylate synthase

Reaction:

(1) (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O₂ = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H₂O₂
(2) (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O₂ = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H₂O₂
(3) (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O₂ = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H₂O₂
(4) (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O₂ = (10aS)-5,10-dihydrophenazine-1-carboxylate + H₂O₂

For diagram of enediyne antitumour antibiotic biosynthesis and pyocyanin biosynthesis, click here

Other name(s):

phzG (gene name)

Systematic name:

1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate:oxygen oxidoreductase

Comments:

Requires FMN. The enzyme, isolated from the bacteria Pseudomonas fluorescens 2-79 and Burkholderia lata 383, is involved in biosynthesis of the reduced forms of phenazine, phenazine-1-carboxylate, and phenazine-1,6-dicarboxylate, where it catalyses multiple reactions.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Xu, N., Ahuja, E.G., Janning, P., Mavrodi, D.V., Thomashow, L.S. and Blankenfeldt, W. Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis. Acta Crystallogr. D Biol. Crystallogr. 69 (2013) 1403–1413. [DOI] [PMID: 23897464]

[EC 1.10.3.16 created 2016]