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Accepted name: lactate—malate transhydrogenase
S)-lactate + oxaloacetate = pyruvate + malate
Other name(s): malate-lactate transhydrogenase
Systematic name: (
Comments: Catalyses hydrogen transfer from C
or C 3 ( 4 S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.
Links to other databases:
BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9077-15-0
Allen, S.H.G. The isolation and characterization of malate-lactate transhydrogenase from
Micrococcus lactilyticus. J. Biol. Chem. 241 (1966) 5266–5275. [PMID: 4289051]
Allen, S.H.G. and Patil, J.R. Studies on the structure and mechanism of action of the malate-lactate transhydrogenase.
J. Biol. Chem. 247 (1972) 909–916. [PMID: 4333516]
[EC 188.8.131.52 created 1972]
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