| EC |
1.1.99.40 |
| Accepted name: |
(R)-2-hydroxyglutarate—pyruvate transhydrogenase |
| Reaction: |
(R)-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + (R)-lactate |
| Other name(s): |
DLD3 (gene name) |
| Systematic name: |
(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming] |
| Comments: |
The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC 1.1.2.4, D-lactate dehydrogenase (cytochrome), and is active with oxaloacetate as electron acceptor forming (R)-malate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Becker-Kettern, J., Paczia, N., Conrotte, J.F., Kay, D.P., Guignard, C., Jung, P.P. and Linster, C.L. Saccharomyces cerevisiae forms D-2-hydroxyglutarate and couples its degradation to D-lactate formation via a cytosolic transhydrogenase. J. Biol. Chem. 291 (2016) 6036–6058. [DOI] [PMID: 26774271] |
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| [EC 1.1.99.40 created 2017] |
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