The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 1.1.5.12     
Accepted name: D-lactate dehydrogenase (quinone)
Reaction: (R)-lactate + a quinone = pyruvate + a quinol
Other name(s): dld (gene name)
Systematic name: (R)-lactate:quinone 2-oxidoreductase
Comments: The enzyme is an FAD-dependent peripheral membrane dehydrogenase that participates in respiration. Electrons derived from D-lactate oxidation are transferred to the membrane soluble quinone pool.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kohn, L.D. and Kaback, H.R. Mechanisms of active transport in isolated bacterial membrane vesicles. XV. Purification and properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli. J. Biol. Chem. 248 (1973) 7012–7017. [PMID: 4582730]
2.  Futai, M. Membrane D-lactate dehydrogenase from Escherichia coli. Purification and properties. Biochemistry 12 (1973) 2468–2474. [PMID: 4575624]
3.  Matsushita, K. and Kaback, H.R. D-lactate oxidation and generation of the proton electrochemical gradient in membrane vesicles from Escherichia coli GR19N and in proteoliposomes reconstituted with purified D-lactate dehydrogenase and cytochrome o oxidase. Biochemistry 25 (1986) 2321–2327. [PMID: 3013300]
4.  Peersen, O.B., Pratt, E.A., Truong, H.T., Ho, C. and Rule, G.S. Site-specific incorporation of 5-fluorotryptophan as a probe of the structure and function of the membrane-bound D-lactate dehydrogenase of Escherichia coli: a 19F nuclear magnetic resonance study. Biochemistry 29 (1990) 3256–3262. [PMID: 2185834]
5.  Dym, O., Pratt, E.A., Ho, C. and Eisenberg, D. The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme. Proc. Natl. Acad. Sci. USA 97 (2000) 9413–9418. [PMID: 10944213]
[EC 1.1.5.12 created 2017]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald