The Enzyme Database

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Accepted name: (S)-2-hydroxy-acid oxidase
Reaction: an (S)-2-hydroxy carboxylate + O2 = a 2-oxo carboxylate + H2O2
Other name(s): hydroxy-acid oxidase A; hydroxy-acid oxidase B; glycolate oxidase; L-2-hydroxy acid oxidase; hydroxyacid oxidase A; L-α-hydroxy acid oxidase
Systematic name: (S)-2-hydroxy carboxylate:oxygen 2-oxidoreductase
Comments: A flavoprotein (FMN). Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids, and was previously listed as EC, glycolate oxidase; the B form preferentially oxidizes long-chain and aromatic hydroxy acids. The rat isoenzyme B also acts as EC, L-amino-acid oxidase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-71-1
1.  Blanchard, M., Green, D.E., Nocito-Carroll, V. and Ratner, S. l-Hydroxy acid oxidase. J. Biol. Chem. 163 (1946) 137–144.
2.  Frigerio, N.A. and Harbury, H.A. Preparation and some properties of crystalline glycolic acid oxidase of spinach. J. Biol. Chem. 231 (1958) 135–157. [PMID: 13538955]
3.  Kun, E., Dechary, J.M. and Pitot, H.C. The oxidation of glycolic acid by a liver enzyme. J. Biol. Chem. 210 (1954) 269–280. [PMID: 13201588]
4.  Nakano, M. and Danowski, T.S. Crystalline mammalian L-amino acid oxidase from rat kidney mitochondria. J. Biol. Chem. 241 (1966) 2075–2083. [PMID: 5946631]
5.  Nakano, M., Ushijima, Y., Saga, M., Tsutsumi, Y. and Asami, H. Aliphatic L-α-hydroxyacid oxidase from rat livers: purification and properties. Biochim. Biophys. Acta 167 (1968) 9–22. [PMID: 5686300]
6.  Phillips, D.R., Duley, J.A., Fennell, D.J. and Holmes, R.S. The self-association of L-α hydroxyacid oxidase. Biochim. Biophys. Acta 427 (1976) 679–687. [PMID: 1268224]
7.  Schuman, M. and Massey, V. Purification and characterization of glycolic acid oxidase from pig liver. Biochim. Biophys. Acta 227 (1971) 500–520. [PMID: 5569122]
8.  Jones, J.M., Morrell, J.C. and Gould, S.J. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. J. Biol. Chem. 275 (2000) 12590–12597. [PMID: 10777549]
[EC created 1972 (EC created 1961, incorporated 1984)]

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