| EC |
1.1.1.88 |
| Accepted name: |
hydroxymethylglutaryl-CoA reductase |
| Reaction: |
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ |
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For diagram of mevalonate biosynthesis, click here |
| Other name(s): |
β-hydroxy-β-methylglutaryl coenzyme A reductase (ambiguous); β-hydroxy-β-methylglutaryl CoA-reductase (ambiguous); 3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous); hydroxymethylglutaryl coenzyme A reductase (ambiguous) |
| Systematic name: |
(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37250-24-1 |
| References: |
| 1. |
Fimognari, G.M. and Rodwell, V.W. Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA). Biochemistry 4 (1965) 2086–2090. |
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| [EC 1.1.1.88 created 1972, modified 2002] |
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