ExplorEnz: EC 1.1.1.44

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1.1.1.44

Accepted name:

phosphogluconate dehydrogenase (NADP⁺-dependent, decarboxylating)

Reaction:

6-phospho-D-gluconate + NADP⁺ = D-ribulose 5-phosphate + CO₂ + NADPH + H⁺

For diagram of the pentose phosphate pathway (early stages), click here

Other name(s):

phosphogluconic acid dehydrogenase; 6-phosphogluconic dehydrogenase; 6-phosphogluconic carboxylase; 6-phosphogluconate dehydrogenase (decarboxylating); 6-phospho-D-gluconate dehydrogenase

Systematic name:

6-phospho-D-gluconate:NADP⁺ 2-oxidoreductase (decarboxylating)

Comments:

The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP⁺. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD⁺-dependent, decarboxylating).

Links to other databases:

BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9073-95-4

References:

1.	Dickens, F. and Glock, G.E. Direct oxidation of glucose-6-phosphate, 6-phosphogluconate and pentose-5-phosphate by enzymes of animal origin. Biochem. J. 50 (1951) 81–95. [PMID: 14904376]
2.	Pontremoli, S., de Flora, A., Grazi, E., Mangiarotti, G., Bonsignore, A. and Horecker, B.L. Purification and properties of β-L-hydroxy acid dehydrogenase. II. Isolation of β-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis. J. Biol. Chem. 236 (1961) 2975–2980. [PMID: 14487824]
3.	Scott, D.B.M. and Cohen, S.S. The oxidative pathway of carbohydrate metabolism in Escherichia coli. 1. The isolation and properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Biochem. J. 55 (1953) 23–33. [PMID: 13093611]
4.	Scott, D.B.M. and Cohen, S.S. The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose phosphate produced from 6-phosphogluconate by the dehydrogenase of E. coli. Biochem. J. 65 (1957) 686–689. [PMID: 13426085]
5.	Bridges, R.B., Palumbo, M.P. and Wittenberger, C.L. Purification and properties of an NADP-specific 6-phosphogluconate dehydrogenase from Streptococcus faecalis. J. Biol. Chem. 250 (1975) 6093–6100. [PMID: 238996]
6.	Yoon, H., Anderson, C.D. and Anderson, B.M. Kinetic studies of Haemophilus influenzae 6-phosphogluconate dehydrogenase. Biochim. Biophys. Acta 994 (1989) 75–80. [DOI] [PMID: 2783298]
7.	Zamboni, N., Fischer, E., Laudert, D., Aymerich, S., Hohmann, H.P. and Sauer, U. The Bacillus subtilis yqjI gene encodes the NADP⁺-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway. J. Bacteriol. 186 (2004) 4528–4534. [DOI] [PMID: 15231785]

[EC 1.1.1.44 created 1961, modified 2013]