EC |
1.1.1.421 |
Accepted name: |
D-apionate oxidoisomerase |
Reaction: |
D-apionate + NAD+ = 3-oxoisoapionate + NADH + H+ |
Glossary: |
3-oxoisoapionate = 2,4-dihydroxy-2-(hydroxymethyl)-3-oxobutanoate |
Other name(s): |
apnO (gene name) |
Systematic name: |
D-apionate:NAD+ oxidoreductase (isomerizing) |
Comments: |
The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. The reaction involves migration of a hydroxymethyl group from position 3 to position 2 and oxidation of the 3-hydroxyl group. Stereospecificity of the product, 3-oxoisoapionate, has not been determined. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Carter, M.S., Zhang, X., Huang, H., Bouvier, J.T., Francisco, B.S., Vetting, M.W., Al-Obaidi, N., Bonanno, J.B., Ghosh, A., Zallot, R.G., Andersen, H.M., Almo, S.C. and Gerlt, J.A. Functional assignment of multiple catabolic pathways for D-apiose. Nat. Chem. Biol. 14 (2018) 696–705. [DOI] [PMID: 29867142] |
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[EC 1.1.1.421 created 2019] |
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