| EC |
1.1.1.401 |
| Accepted name: |
2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) |
| Reaction: |
2-dehydro-3-deoxy-L-rhamnonate + NAD+ = 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ |
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For diagram of L-rhamnose metabolism, click here |
| Other name(s): |
2-keto-3-deoxy-L-rhamnonate dehydrogenase |
| Systematic name: |
2-dehydro-3-deoxy-L-rhamnonate:NAD+ 4-oxidoreductase |
| Comments: |
The enzyme, characterized from the bacteria Sphingomonas sp. SKA58 and Sulfobacillus thermosulfidooxidans, is involved in the non-phosphorylative degradation pathway for L-rhamnose. It does not show any detectable activity with NADP+ or with other aldoses. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Watanabe, S. and Makino, K. Novel modified version of nonphosphorylated sugar metabolism - an alternative L-rhamnose pathway of Sphingomonas sp. FEBS J. 276 (2009) 1554–1567. [DOI] [PMID: 19187228] |
| 2. |
Bae, J., Kim, S.M. and Lee, S.B. Identification and characterization of 2-keto-3-deoxy-L-rhamnonate dehydrogenase belonging to the MDR superfamily from the thermoacidophilic bacterium Sulfobacillus thermosulfidooxidans: implications to L-rhamnose metabolism in archaea. Extremophiles 19 (2015) 469–478. [DOI] [PMID: 25617114] |
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| [EC 1.1.1.401 created 2016] |
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