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Your query returned 1 entry. 
Printable version
| EC | 1.1.1.381 | ||
| Accepted name: | 3-hydroxy acid dehydrogenase | ||
| Reaction: | L-allo-threonine + NADP+ = aminoacetone + CO2 + NADPH + H+ (overall reaction) (1a) L-allo-threonine + NADP+ = L-2-amino-3-oxobutanoate + NADPH + H+ (1b) L-2-amino-3-oxobutanoate = aminoacetone + CO2 (spontaneous) |
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| Glossary: | L-allo-threonine = (2S,3S)-2-amino-3-hydroxybutanoic acid aminoacetone = 1-aminopropan-2-one L-2-amino-3-oxobutanoate = (2S)-2-amino-3-oxobutanoate |
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| Other name(s): | ydfG (gene name); YMR226c (gene name) | ||
| Systematic name: | L-allo-threonine:NADP+ 3-oxidoreductase | ||
| Comments: | The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). | ||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
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